Message from the Director & Board

For BPRC, 2019 was another eventful year.

The quality of our scientific output goes steady on, and BPRC researchers published several important papers in high-ranking journals. The average impact factor of these 30 scientific communications was fixed at 4.69.




Our hallmark publication in 2019 was published in Nature Medicine and centered around the theme of “Local BCG vaccination to prevent tuberculosis infection and disease”. This approach has been picked up by the scientific community and, this vaccination strategy may become an important health care asset in the near future.

BPRC is sponsored for a large part by the Ministry of OCW. Our ambition plan was approved by the ministry, and as such it was determined that our colony size will comprise about 1000 individuals in 2025. At 31st December 2019, the colony counted 1277 individuals which reflects a considerably drop in numbers. The reduction was mainly achieved by managing the breeding population carefully.

In 2019, BPRC conducted 154 animal experiments, which represents a relatively low number (see figure below). This is in part due to the “counting systematics” that is used in the Netherlands as defined by Dutch law. In more detail, an animal in experiment is “counted” at the end of an experiment. In 2019 a substantial number of experiments were started that will pass the boundary of the year. Therefore, it is anticipated that the respective number of experiments in 2020 will be somewhat higher. For that reason, BPRC prefers to works with average numbers per 5 years, which provides a more accurate estimate and the highs and lows are flattened. One can indeed see in the graphic representation below, that we have years with numbers deviating substantially from the mean. Again, this is most often explained by the length of the studies, surpassing the boundary of the year. Anyway, the trend is that the numbers tend to get lower. In 2025, BPRC will have to fulfill the criteria set by the government that we will maximize the number of animal experiment 120-150 a year. We are on track of achieving this.




The Supervisory Board and the Director congratulate the scientific and supporting staff on the obtained results.

Prof. dr. R.E. Bontrop
Director of BPRC

Mr. J. Vrolijk
Chairman of the Supervisory Board